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Prabhakar, Nanduri R.

One or more keywords matched the following properties of Prabhakar, Nanduri R.

Property	Value
overview	Nanduri R. Prabhakar, Ph.D., D.Sc. Harold Hines Jr. Professor of Medicine Director, Center for Systems Biology Director, Oxygen Sensing Department of Medicine The revolutionary advances in cell and molecular biology as well as in genetic engineering in the past half-a-century have provided spectacular insights into our understanding of structure and function of biological systems at the molecular, cellular and sub-cellular levels. Shifting the research emphasis from organ (or from the whole body levels) to cellular and molecular physiology has resulted in a rapid decline in research on physiology at the systems level. While the reductionist approaches are powerful, they have brought into focus a major gap that has developed between our understanding of the molecular/cellular alterations and their impact at the organ and/or whole animal level. Integrative physiology, on the other hand, embraces the concepts of cell/molecular physiology, biochemistry and applies these concepts and experimental approaches to understand the function at the level of whole animal or organ. Realizing its importance, the University of Chicago established the Institute for Integrative Physiology (IIP) at the Biological Sciences Division as of October 2010. The main missions of IIP are to provide intellectual home for faculty members interested in various areas of Physiology to foster interactive research programs and oversee physiology education to medical, graduate and undergraduate students. These missions are supported by exceptional faculty in the IIP. We believe that IIP reaches far beyond the BSD to enhance the national and international visibility of Physiological research at the University of Chicago and provide training to the next generation of leaders in Physiology.

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Value

overview

Nanduri R. Prabhakar, Ph.D., D.Sc. Harold Hines Jr. Professor of Medicine Director, Center for Systems Biology Director, Oxygen Sensing Department of Medicine The revolutionary advances in cell and molecular biology as well as in genetic engineering in the past half-a-century have provided spectacular insights into our understanding of structure and function of biological systems at the molecular, cellular and sub-cellular levels. Shifting the research emphasis from organ (or from the whole body levels) to cellular and molecular physiology has resulted in a rapid decline in research on physiology at the systems level. While the reductionist approaches are powerful, they have brought into focus a major gap that has developed between our understanding of the molecular/cellular alterations and their impact at the organ and/or whole animal level. Integrative physiology, on the other hand, embraces the concepts of cell/molecular physiology, biochemistry and applies these concepts and experimental approaches to understand the function at the level of whole animal or organ. Realizing its importance, the University of Chicago established the Institute for Integrative Physiology (IIP) at the Biological Sciences Division as of October 2010. The main missions of IIP are to provide intellectual home for faculty members interested in various areas of Physiology to foster interactive research programs and oversee physiology education to medical, graduate and undergraduate students. These missions are supported by exceptional faculty in the IIP. We believe that IIP reaches far beyond the BSD to enhance the national and international visibility of Physiological research at the University of Chicago and provide training to the next generation of leaders in Physiology.

One or more keywords matched the following items that are connected to Prabhakar, Nanduri R.

Item Type	Name
Concept	Cell Differentiation
Concept	Cell Nucleus
Concept	Cell Membrane
Concept	Chemoreceptor Cells
Concept	Sensory Receptor Cells
Concept	Respiratory Mechanics
Concept	Cell Respiration
Concept	Chromaffin Cells
Concept	Tumor Cells, Cultured
Concept	PC12 Cells
Concept	Cell Proliferation
Concept	HEK293 Cells
Concept	Insulin-Secreting Cells
Concept	Cell Hypoxia
Concept	Cell Cycle Checkpoints
Concept	Endothelial Cells
Concept	Cell Line, Tumor
Concept	Cell Line
Concept	Cell Survival
Concept	Cells, Cultured
Academic Article	Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells.
Academic Article	Cell selective induction and transcriptional activation of immediate early genes by hypoxia.
Academic Article	Possible genomic mechanism involved in control systems responses to hypoxia.
Academic Article	NO and CO as second messengers in oxygen sensing in the carotid body.
Academic Article	Norepinephrine inhibits a toxin resistant Ca2+ current in carotid body glomus cells: evidence for a direct G protein mechanism.
Academic Article	Ca2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage-activated Ca2+ channels.
Academic Article	Induction of immediate early response genes by hypoxia. Possible molecular bases for systems adaptation to low pO2.
Academic Article	Dual influence of nitric oxide on gene regulation during hypoxia.
Academic Article	Oxygen sensing by the carotid body chemoreceptors.
Academic Article	Intracellular pathways linking hypoxia to activation of c-fos and AP-1.
Academic Article	Release of dopamine and norepinephrine by hypoxia from PC-12 cells.
Academic Article	Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism.
Academic Article	HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body.
Academic Article	Role of c-fos in hypoxia-induced AP-1 cis-element activity and tyrosine hydroxylase gene expression.
Academic Article	CO2/HCO3- modulates K+ and Ca2+ currents in glomus cells of the carotid body.
Academic Article	Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.
Academic Article	The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.
Academic Article	Ventilatory changes during intermittent hypoxia: importance of pattern and duration.
Academic Article	Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels.
Academic Article	Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway.
Academic Article	Intermittent hypoxia: cell to system.
Academic Article	Peripheral and central chemosensitivity: multiple mechanisms, multiple sites? A workshop summary.
Academic Article	Chemoreceptor responses to substance P, physalaemin and eledoisin: evidence for neurokinin-1 receptors in the cat carotid body.
Academic Article	Gene regulation during intermittent hypoxia: evidence for the involvement of reactive oxygen species.
Academic Article	Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia.
Academic Article	Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction.
Academic Article	Peripheral chemoreceptors in health and disease.
Academic Article	Oxidative stress in the systemic and cellular responses to intermittent hypoxia.
Academic Article	Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration.
Academic Article	CO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells.
Academic Article	Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups.
Academic Article	Detection of oxygen sensing during intermittent hypoxia.
Academic Article	Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling.
Academic Article	Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.
Academic Article	Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia.
Academic Article	Regulation of breathing by tissue oxygen: evidence from mutant mice with Presbyterian hemoglobinopathy.
Academic Article	Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia.
Academic Article	Effect of adenosine on chemosensory activity of the cat aortic body.
Academic Article	Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.
Academic Article	Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
Academic Article	Occurrence of neutral endopeptidase activity in the cat carotid body and its significance in chemoreception.
Academic Article	Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells.
Academic Article	Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.
Academic Article	Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS.
Academic Article	O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?
Academic Article	Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells.
Academic Article	NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats.
Academic Article	NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells.
Academic Article	Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS.
Academic Article	Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation.
Academic Article	Involvement of ventral medullary surface in respiratory responses induced by 2,4-dinitrophenol.
Academic Article	Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein.
Academic Article	Oxygen sensing in the body.
Academic Article	Analysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats.
Academic Article	Carbon monoxide: a role in carotid body chemoreception.
Academic Article	Effect of arterial chemoreceptor stimulation: role of norepinephrine in hypoxic chemotransmission.
Academic Article	Inhibitory sympathetic action on the carotid body responses to sustained hypoxia.
Academic Article	Contrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells.
Academic Article	Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2.
Academic Article	Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.
Academic Article	Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing.
Academic Article	Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Academic Article	Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: II. Responses of respiratory muscles and their motor nerves.
Academic Article	Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
Academic Article	Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: I. Ventilatory responses.
Academic Article	NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells.
Academic Article	Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat.
Academic Article	Nitric oxide in the sensory function of the carotid body.
Academic Article	Effect of focal cooling of central chemosensitive areas on cerebral ischemic response.
Academic Article	Responses of hypoglossal and phrenic nerves to decreased respiratory drive in cats.
Academic Article	Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345.
Academic Article	Selective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345.
Academic Article	Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2.
Academic Article	Gases as chemical messengers in the carotid body. Role of nitric oxide and carbon monoxide in chemoreception.
Academic Article	Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.
Academic Article	Endogenous H2S is required for hypoxic sensing by carotid body glomus cells.
Academic Article	Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase.
Academic Article	L-type Ca(2+) channel activation regulates induction of c-fos transcription by hypoxia.
Academic Article	Chemosensing at the carotid body. Involvement of a HERG-like potassium current in glomus cells.
Academic Article	Peripheral chemosensitivity in mutant mice deficient in nitric oxide synthase.
Academic Article	Augmentation of calcium current by hypoxia in carotid body glomus cells.
Academic Article	Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation.
Academic Article	Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species.
Academic Article	Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide.
Academic Article	Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.
Academic Article	Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration.
Academic Article	Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes.
Academic Article	Effect of adenosine on isolated and superfused cat carotid body activity.
Academic Article	Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.
Academic Article	Neurotransmitters in the carotid body.
Academic Article	Influence of central chemoreceptor afferent inputs on respiratory muscle activity.
Academic Article	Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms.
Academic Article	Peripheral chemoreceptors: function and plasticity of the carotid body.
Academic Article	Mutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis.
Academic Article	Is insulin the new intermittent hypoxia?
Academic Article	TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
Academic Article	Hypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression.
Academic Article	Central and peripheral factors contributing to obstructive sleep apneas.
Academic Article	Impairment of pancreatic ß-cell function by chronic intermittent hypoxia.
Academic Article	CaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body.
Academic Article	Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation.
Academic Article	Xanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia.
Academic Article	Protein kinase G-regulated production of H2S governs oxygen sensing.
Academic Article	HIF-1a activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase.
Academic Article	Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications.
Academic Article	Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.
Academic Article	CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia.
Academic Article	Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia.
Academic Article	Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients.
Academic Article	HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.
Academic Article	Measurement of Sensory Nerve Activity from the Carotid Body.
Academic Article	Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia.
Academic Article	H2S mediates carotid body response to hypoxia but not anoxia.
Academic Article	Epigenetic changes by DNA methylation in chronic and intermittent hypoxia.
Academic Article	Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.
Academic Article	Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia.
Academic Article	Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.
Academic Article	Hypoxia-inducible factor-1 mediates pancreatic ß-cell dysfunction by intermittent hypoxia.
Academic Article	Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells.
Academic Article	Lysine demethylase KDM6B regulates HIF-1a-mediated systemic and cellular responses to intermittent hypoxia.
Academic Article	Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.
Academic Article	Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia.
Academic Article	Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells.
Academic Article	P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
Academic Article	Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

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